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s.EB+U;BsZ$ 1fOfKfu~tFFP+V ҉Vt=F])ʍDS މCF;F r)F FE@@ @UtV11ҋ^$t&Fu 0u9s-fp?tax![^_]Ít&'UoS] M #^iҁu)Ӊ] i`z)щM[]&'U tx$v Atu taBxu xah%lhwhwphf $,0$UWVS,}D$D$<$5 !ˆQ t^ !ˆQƅuL|$D$$t8$L u1Q uA1륍t&D$#$t1t&< t< t4zD$=4$8P1 T t tȉD$$xD$4$U $T$ED$D$U$*EUD,[^_]Ðt&UtE D$.D$ $,1[^_]á D$D$$-D$ /딋E D$3-D$ $,n \$D$-$ Kt&'UWVS,D$$EED$ D$ED$U T$E$HD$$,ۉ11t&ED$D$$$b9Eu~#ED$N-$uD$4$iUU2t1҉vE9U$t<$l,[^_]ÍU D$$.T$$,[^_]Í'UVS0u D$$ ËED$ \$t$D$E$~1ED$$^E$A9Eu$0[^]Ð t$D$R-$ 0[^]Ít&'UVS0u D$$ ËED$ \$t$D$E$M~9ED$D$$U$9Eu$0[^]Ð t$D$i-$S0[^]ÍvUVS0u D$$ eËED$ \$t$D$E$~9ED$D$$U$9Eu$I0[^]Ð t$D$i-$0[^]ÍvUVS0u D$$ ËED$ \$t$D$E$~9ED$D$$U$)9Eu$0[^]Ð t$D$i-$0[^]ÍvUVS0u D$$ ËED$ \$t$D$E$=~9ED$D$$U$y9Eu$0[^]Ð t$D$i-$C0[^]ÍvUWVSD$$WEED$ D$ED$u t$E$5E-uu(Eۃ6yuu"Exeuxsux&uu}ouExnu xuu}1uExuu-u(!ËE}nuu~ou ~!ËE}ouu~fu~fu~!ÍE}0u-u~u$uE$4[^_]ÍvEtE$[^_]Íu D$-t$$`몐U]Ít&'UWVSO +)t$1ED$E D$E$9rރ [^_]Ë$ÐUS~t~fЋu[]ÐUS[ÌY[The program was halted because You can use the standalone command-line version with --time-limit 0 option that switch off time limits. basic_string::_S_construct NULL not validYet Another Digging For DNA Motifs Gibbs Sampler�<h2>Looking for DNA motifs Gibbs sampler (SeSiMCMC) result.</h2>����*Looking for DNA motifs Gibbs sampler (SeSiMCMC)����Trying to get atgc char from something other then 1..4. ����Positions of motifs in test bunch are: �The program was stopped because there are �� sequences that can meet the lenght requirements����It looks like something is wrong. ��<?xml version='1.0' encoding='UTF-8'?>��<comment>All locations are 1-based</comment>����SeSiMCMC. Looking - for - motifs by MCMC project. (c) A. Favorov 2001-2009.�Usage : SeSiMCMC [options] [(--config-file|-f) config-file] < (FastA input).����SeSiMCMC -i FastA_input_file is a good how-do-you-do.���To get a complete configuration file, say -w in addition to other options:��the configuration file of the task will be outputed instead of results.�Some options that affect only output form, like --html or --cgi can be provided�For options and configuration tags information, refer to readme file.���retrieve_other_sites_threshold=�retrieve_other_sites=pure_smart�local_step_cycles_between_adjustments=��cycles_with_minor_change_to_say_cold=���annealings_number_maximum_is_to_be_global_for=��steps_number_maximum_is_to_be_global_for=���File %s cannot be opened for read. �Input file %s cannot be opened for read. ���Output file %s cannot be opened for write. �Masked part value is not double. ���Flanks length is not an unsigned int. ��Time limit is not an unsigned int. �Unknown mode. I will keep two threads mode. ����Unknown symmetry. I will keep generic mode. ����Unknown (deprecated tag input_caps) caps mode. I will keep off. ����Unknown caps mode. No change. ��Incorrect caps mode sequence. No change. ���Unknown post-retrieving instruction. I will keep it off. ���retrieve_other_sites_threshold��local_step_cycles_between_adjustments���Unknown annealing criterion. I will keep the information-based one. ����cycles_with_minor_change_to_say_cold����annealings_number_maximum_is_to_be_global_for���steps_number_maximum_is_to_be_global_for����Absence prior value is not double. �Motif length value is not unsigned int. ����Maximal motif length value is not unsigned int. ����Minimal motif length value is not unsigned int. ����--retrieve-other-sites-threshold����Number of the threshold site is not an unsigned int. ���Local cycles between adjustments value is not unsigned long. ���--site-positions-annealing-criterion����Local cycles to stop annealing value is not unsigned long. �Annealing stop bound level not double. �Annealings duration maximum is to hold to be global value is not unsigned int. �Steps naumber maximum is to hold to be global value is not unsigned long. ��Number of forbidden adjsjmts to fail chain is not unsigned int. ����Number of chains to try is not unsigned int. ���--cycles_per_annealing_attempt��Number of cycles per annealing attempt is not unsigned int. ����Number of annealing attempts is not unsigned int. ��Seed 1 is not an unsigned long. ����Seed 2 is not an unsigned long. ����It seemes to me that some arguments are unknown or duplicated...����I will output the configuration if you give me data and exit.���Non-zero threshold is given for no posprocessing... I put it back to 0. ����Non-zero threshold is given for "pure smart" ... I put it back to 0. ���Zero threshold for "smart" ... It is "pure smart", actually. ���You have given me a nonpositive background counter.�Random generator is created... �One sequence or nothing is given... ����One good sequence or no good sequences is given... �The length requirements from the data contradict with the ��The slow optimisation mode makes no sense when the site length is pre-given. ���The sampler was not secondary annealed after ��� steps made. The initial length was ���� initial annealing attempts failed, initial pattern length was �The sampler did not find a good maximum after �� steps made. Initial pattern length was ����The sampler has failed by failing all the �� chains. Initial pattern length was ����The state we found has zero site length! ���<!-- The configuration parameters: �<comment name="configuration_parameters"> ��#The configuration parameters: �Finished. Giving results..... ��--pure-smart-retrieve-other-sites���--information-annealing-criterion���--correlation-annealing-criterion�the given time limit of � seconds is used. �vector::_M_fill_insert�vector::_M_insert_aux�stdin�<html>�<head>� (SeSiMCMC) output.

Input FastA file name:

#Input FastA file name:/dev/null%Y %b %d %X %Z+Id: started from IP:offoneallbasic_string::substrTrying to interpret %1i as an atgc number (1..4). Fake|seq%02i
-Id: (IP:) finished at %Id: worked seconds.core version is among input sequences. SeSiMCMC < (FastA input) oronly via command-line keys.unknown_caps_modeoff-one-all-mode=one_strandtwo_strandsunknownsymmetry=motif_absence_prior=adjust_motif_length=spaced_motif=common_background=adaptive_pseudocouts=maximal_motif_length=minimal_motif_length=retrieve_other_sites=noretrieve_other_sites=yesretrieve_other_sites=smartdumb_trim_edges=caps=adjustments_during_annealing=annealing_criterion=site_positionsinformationcorrelationminor_change_level=slow_optimisation=chain_fails_after=chains_to_try=cycles_per_annealing_attempt=annealing_attempts=random_seed_1=random_seed_2=background_A=background_T=background_G=background_C=undefined-?-h--help--fake--config-file-f--write-config-w--quiet-q-q+-q--i---input---input-file--i--input--input-file-in--input-name--input-file-name--output-file--output-fasta--masked-part--flanks-length--flanks-k--show-spaced-bases--ssb--not-show-spaced-bases--hsb--cgi--xml--html--output-unreliable-result--unrel--logfile--log--ip--id--time-limit--time-tl--output-tables--not-output-tablesmotif_absence_prioradjust_motif_lengthspaced_motifinput_capsneglectinitialobligatoryadaptive_pseudocoutscommon_backgroundbackground_Abackground_Tbackground_Gbackground_Cmaximal_motif_lengthminimal_motif_lengthretrieve_other_sitespure_smartdumb_trim_edgesadjustments_during_annealingannealing_criterionminor_change_levelslow_optimisationchain_fails_afterchains_to_trycycles_per_annealing_attemptannealing_attemptsrandom_seed_1random_seed_2--one-strand--no-symmetry-tr-rp--tandems--repeats-o--absence-prior-p--not-adjust-length-a--a+--no-spacers--not-spaced--spaced--length-l--A--background-ABackground_A is not double. --T--background-TBackground_T is not double. --G--background-GBackground_G is not double. --C--background-CBackground_C is not double. --footprint--footprints--fp--footprinta--footprintsa--fpa--caps--caps-mode--iics--aics--oics--nics--adaptive-pseudocouts--adap--nadap--common-background--no-common-background--maximal-length--max-length-l+--minimal-length--min-length-l---not-retrieve-other-sites--no-retrieve-r---retrieve-smart-rs--retrieve-pure-smart-rps-r+-r--not-trim-edges--not-trim--trim---trim--not-dumb-trim-edges--not-dumb-trim--dumb-trim---dumb-trim--local-cycles-e--annealing-adjustments-n+-n--sac-iac-cac--cycles-to-say-cold-y--annealing-stop-level-v--global-area-annealings-g--global-area-steps-t--slow-optimisation--slow-optimization-s--chain-fails-after--chains-to-try--ac--annealing-attempts--at--random-seed-1--seed-1--seed1--random-seed-2--seed-2--seed2--no-permutations--no-permutYou have given only background counters.fake generated datareading FastA Sequence bunch is read... the length parameters. Sampler is created...All of The slow mode search failed. --> Motifs of length with gap [] are located at:(compl)too-longabsentCannot output report data Deleting sampler... --version--noquiet--hide-spaced-bases--two-strands--palindromes--adjust-length--spacers--initial-input-caps--annealing-input-caps--obligatory-input-caps--neglect-input-caps--no-adaptive-pseudocouts--smart-retrieve-other-sites--retrieve-other-sites--trim-edges--dumb-trim-edges--not-annealing-adjustmentsSeSiMCMC 4.35ȅ5Hxatgc13AtgcExceptionP13DumbException  4(wx(wx4ĩDd4PdTPȅ411DiagnosticsXĨĨ`11LetterOrder    @  N36LookingForAtgcMotifsMultinomialGibbs31LostInSpaceOnSecondaryAnnealingEN36LookingForAtgcMotifsMultinomialGibbs33AllInitialAnnealingAttemptsFailedEN36LookingForAtgcMotifsMultinomialGibbs20LostInSpaceOnTracingEN36LookingForAtgcMotifsMultinomialGibbs19TooMuchChainsFailedEN36LookingForAtgcMotifsMultinomialGibbs18TimeLimitExceptionEN36LookingForAtgcMotifsMultinomialGibbs23TooResrtrictiveCapsModeEN36LookingForAtgcMotifsMultinomialGibbs16SlowSearchFailedE@@@ A???ffffff?Total counters:Nonpattern counters: motifs:Trying to start counts from empty data set. The background is not 0 and not 4. Pattern counters gathered from Direction of sequences accounted: X @`P.''4 @`P.`'(| @0 `@(@'' @0 `@(&`8 @0 `@(P%$25DoubletAtgcSymbolsCounterȅ X 18AtgcSymbolsCounterȅ@  21DoubletSymbolsCounterȅd  23SymmetricSymbolsCounterȅ  14SymbolsCounter ȅ HN14SymbolsCounter23OtherLengthPWMExceptionE9B.?Try to put mask from results of an alien sequence. A sequence name was overriden: maybe, it is an input file inconsistency? Fasta reader has found nonblank line before name. Fasta reader has found two NBRF comments in one record. The pre-processed string that gained the error was: We treat '-' as a 1-base gap, which cannot be inside a site. If you mean something else, change the FastA file. by: Trying to read symbol '' as nucleoutide. . ȅH17IOStreamException . Balancing complements... Exiting. , gap Shift steps and regular adjustments made). The state is :F is ) is : and gap adjustment (checkpoint after The state after adjustment : We make There are sequences,Initial caps mode: each site contains caps onlyAnnealing caps mode: Refinement caps mode: An annealing will go until cycles.We will do annealing attempts. The pattern length is notWe look for motif between length, starting with from one attempt to another. during annealing. Initial annealing attempt #Annealing attempt failed. Distance(annealing)= StrongIC= in position. cycles on the attempt # The maximum is global if steps do not change it. A chain fails after We have chain attempts. ***Local maximum (F=, G= ) : ). 's adjacent one). A chain has failed !!! !!!LostInSpaceOnTracing caught.TooMuchChainsFailed caught.with G=$Revision: 1037 $Trying to make draw more than the most possible. We reinit the sampler with length Trying to measure distance btw a PWN and a KullbakCounter of different lengthes. and length adjustment (checkpoint after ; information per pattern position is The state is too sparse to do anything.Contradictory state. Length is more than possible. Globally optimal state ( info/pos=Globally optimal state is the sameContradictory state. All shifts are masked. ; information per pattern position (G) is The adjustment has not change the state. local step cycles between positional adjustmentThe maximal sequence length is The median sequence length is The minimal sequence length is The default start motif length is The maximal reasonable motif length is The minimal reasonable motif length is Prior of motif absence in a sequence is each site contains at least one capWe are looking for palindromes. We are looking for motifs on both threads. We are looking for motifs on one thread. We are looking for double repeats on one thread. We are looking for double repeats on both threads. adjacent local cycles result in a minor change. A minor change is when scalar products of statesbefore and after the cycle is more than A minor change is when information distance between statesbefore and after the cycle is less than times the information content of a state. Annealing attempt fails if it has not succeeded after changing during an annealing attempt. We vary motif length during adjustments and from one attempt (chain) to another. We do not vary motif length during adjustments andWe reduce pseudocounts sum down to Unknown annealing test mode!!!. Starting initial annealing attempts at The sampler initialised for the annealing attempt The sampler is initially annealed ... It took The sampler is finally annealed ... adjacent forbidden adjustments. ***Global maximum, so returning ... (F=***Local maximum found by adjustment (G=The sampler-is-annealed test failed (All chains failed. Throwing exception at maxG=lost in space. Throwing exception at maxG=Ordinary return from find_maximum.LostInSpaceOnSecondaryAnnealing caught.AllInitialAnnealingAttemptsFailed caught.&&& First length was counted. The best was: &&& A length was counted. The best was: $Id: MCMC.cpp 1037 2009-04-23 23:34:37Z favorov $cqnP[]t0X[`cqnZ@T]t0XpZ`o XZp49LookingForAtgcRepeatsInTwoThreadsMultinomialGibbsȅ48LookingForAtgcRepeatsInOneThreadMultinomialGibbsȅ 41LookingForAtgcPalindromesMultinomialGibbsȅ` 48LookingForAtgcMotifsInTwoThreadsMultinomialGibbsȅ 47LookingForAtgcMotifsInOneThreadMultinomialGibbsȅ @36LookingForAtgcMotifsMultinomialGibbs ĨĨĨĨN36LookingForAtgcMotifsMultinomialGibbs24LenghtRequirementsFailedE??-q=oT! @;f?Trying to fing complement to symbol 'I cannot asymmetrically trim a spaced motif! There was an attempt to trim down to a length that is less than the shortest sensible one! The list of sitesThe best information content for different site lengthes: direct repeat sites on both strands of direct repeat sites on one strand of The sampler has tested the lengths in [Then the site was trimmed down to length !!! The motif length is the minimal tested length.!!! It possibly means that the result is almost garbage.!!! Try to shift the band of to use slow mode.!!! The motif informative part is just the shortest!!! significant pattern length. additional sites found by postprocessingThe latter are marked with "*" in the table.
All the positions are 0-based.

dynamic (it depends on positions of sites)common, it is gathered from the data
Length
#The best information content for different site lengthes:#the sampler has tested the lengths in [#then the site was trimmed down to length #!!! The motif length is the minimal tested length.#!!! It possibly means that the result is almost garbage.#!!! Try to shift the band of to use slow mode.#!!! The motif informative part is just the shortest#!!! significant pattern length. were added by post-sampling processing.They are marked with "*" at line end.#The background symbols probabilities:#The positions symbols probabilities forming the motif:#the output below is sites list. Every string is:#gene_id position length score '. @\AB I YAB F @AB Fd@X0AB  pX]AB EYu^AB $0AB LN Zf&^AB MF pZf6^AB MF 8ZfF^AB MF \P[fV^AB MF [ff^AB MF 0\AB F ]v^AB F ^AB F R^AB F 4@ ^AB I X`^AB F |c_AB F gAB I$#J1_AB BC nAB F$oZl_AB BC$8q_AB BF$`tZ_AB BC @&"`AB C$)AB FL *AB E @w 1`AB I *R`AB F @P l`AB I dp `AB I p`AB F @ aAB F ` daAB F$aAB QW$PaAB QW$D bAB QW$l$bAB QW$HbAB QW$lbAB QW *bAB F д*bAB F ,*bAB F P0*,cAB F t`D`cAB I eAB I@-0AB $ eAB FJ AB F (AB C Lp-wfAB F$pqAB II bdded>\d \!d!c"d%c%d*b+c+c-c-c-c.c/c4c4b8b8b:b;b;bbBbFaIbOaOaPaPaQ`RaUcU`V`V`WbW_W_X_X_Y^Y^Z]Zd[][d[e[\[[[\\\\\\\\\^_^\ddd\}H7":                [*=/l/ / /-/-/-/////uk': i!! ! o! #!!   !  !!!}$^]^^^^]___ g g g gg\ggf>_f_g>fggg f!g$e%f&e'c(d,e,e.e/e/e/e1e5e8d>d>d@d@dAdASdCdHdKdP{dSdUcUcVcV`WbWbXbXbYaZd[a[e[`\`\g]_]g]g^^^^^^^^^^^^__aaa_ggg_}H09@X@-n    \o؆  TĠoooƞZjzʥڥ *:JZjzʦڦ *:JZjzʧڧ *:JZjzʨڨ *:JZjzʩک *:JZjzʪڪ *:JZjzʫګ *:JZjzʬTQNKHEB?<2/,)&# GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036]GCC: (SUSE Linux) 4.3.1 20080507 (prerelease) [gcc-4_3-branch revision 135036].shstrtab.interp.note.ABI-tag.note.SuSE.gnu.hash.dynsym.dynstr.gnu.version.gnu.version_r.rel.dyn.rel.plt.init.text.fini.rodata.eh_frame_hdr.eh_frame.gcc_except_table.ctors.dtors.jcr.dynamic.got.got.plt.data.bss.comment TThh !0L,o6 ؆> FoƞSob Ġ k TT! t%0oDD%z,|8\\eeH D.D3L ~~ x x
The background symbols probabilitiesThe table of positional symbols probabilities forming the motifThe description of sites
Gene IdPositionLengthScoreSite-as-in-motif