Supplementary Table 1. E.coli genes used for construction of the ArcA binding signal. With the exclusion of one gene this set coincides with that used in (McGuire et al, 1999).

Name	Function	Reference	Experimental method
icdA	isocitrate dehydrogenase, specific for NADP+	Chao et al, 1997	DNase I footprinting and other methods
aldA	aldehyde dehydrogenase, NAD-linked	Pellicer, Lynch et al, 1999	DNA binding assays and other methods
lldP	L-lactate permease	Lynch et al, 1996	DNA binding assays and other methods
cydAB	cytochrome D terminal oxidase, polypeptide subunit I	Lynch et al, 1996	DNA binding assays and other methods
gltA	citrate synthase	Lynch et al, 1996	DNA binding assays and other methods
sdhC	succinate dehydrogenase, hydrophobic subunit	Lynch et al, 1996	DNA binding assays and other methods
sodA	superoxide dismutase, manganese	Hassan et al, 1992	Beta-Galactosidase assays
lpdA	lipoamide dehydrogenase (NADH)	Cunningham et al, 1998	Beta-Galactosidase assays and other methods
glcCD	regulator of degradation of small molecules, carbon compounds	Pellicer, Fernandez et al, 1999	DNA binding assays and other methods

References

Chao,G., Shen,J., Tseng,C.P., Park,S.J., and Gunsalus,R.P. (1997) Aerobic regulation of isocitrate dehydrogenase gene (icd) expression in Escherichia coli by the arcA and fnr gene products. J. Bacteriol., 179 (13), 4299-4304.

Cunningham,L., Georgellis,D., Green,J. and Guest,J.R. (1998) Co-regulation of lipoamide dehydrogenase and 2-oxoglutarate dehydrogenase synthesis in Escherichia coli: characterisation of an ArcA binding site in the lpd promoter. FEMS Microbiol. Lett., 169(2), 403-408.

Hassan,H.M. and Sun,H.C. (1992) Regulatory roles of Fnr, Fur, and Arc in expression of manganese-containing superoxide dismutase in Escherichia coli. Proc. Natl. Acad. Sci. USA, 89 (8), 3217-3221.

Lynch,A.S. and Lin,E.C. (1996) Transcriptional control mediated by the ArcA two-component response regulator protein of Escherichia coli: characterization of DNA binding at target promoters. J. Bacteriol., 178 (21), 6238-6249.

McGuire,A. M., De Wulf,P., Church,G.M. and Lin, E. C. C. (1999) A weight matrix for binding recognition by the redox-response regulator ArcA-P of Escherichia coli. Molecular Microbiology, 32 (1), 219-221.Pellicer,M.T., Fernandez,C., Badia,J., Aguilar,J. Lin,E.C. and Baldom,L. (1999) Cross-induction of glc and ace operons of Escherichia coli attributable to pathway intersection. Characterization of the glc promoter. J. Biol. Chem., 274 (3), 1745-1752.

Pellicer,M.T., Lynch,A.S., De Wulf,P., Boyd,D., Aguilar,J. and Lin,E.C. (1999) A mutational study of the ArcA-P binding sequences in the aldA promoter of Escherichia coli. Mol. Gen. Genet., 261 (1), 170-176.